Last name Santo Domingo (Santo Domingo 
) , around the globe, is a rare cognomen. The family name Santo Domingo is characteristic of Latin America and the Caribbean, particularly Puerto Rico, where it is quite a rare surname, the Dominican Republic, and Panama, where it is a rare surname. In absolute terms, it most frequently occurs in the Dominican Republic, Philippines, and Spain. Very seldom, Santo Domingo is the forename as well as the last name.
| VARIANT | COUNTRY |
|---|---|
| Santo Domingo | Philippines, Puerto Rico, Ecuador, Dominican Republic, Spain |
| julio mario santo domingo pumarejo Colombian billionaire, magnate (1923-2011), CO (b. 1923) |
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| alejandro santo domingo dávila Colombian businessman, US (b. 1977) |
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| tatiana santo domingo rechulski Colombian fashion designer, CH (b. 1983) |
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